Listen as Dr. Silver talks about autoimmune disease with NaturalNews.com! (August 2015)
- RHEUMATOID ARTHRITIS
- GRAVE’S DISEASE
- MULTIPLE SCLEROSIS
- TYPE 1DIABETES
WHAT IS THE IMMUNE SYSTEM?
To discuss autoimmune disease, I want to first discuss what the immune system is. The physiological function of the immune system is defense against the infectious microbes; however, even noninfectious foreign substances can elicit an immune response. Under some situations even cell molecules can elicit immune response. This is what is called the autoimmune response and gives you disease.
INNATE VS. APADTIVE IMMUNITY:
INNATE AND ADAPTIVE IMMUNITY IMBALANCE LEADS TO AUTOIMMUNE DISEASE
Defense against microbes is mediated by the early reactions of innate immunity and the later responses of adaptive immunity.
INNATE immunity also called natural or native immunity. This provides the early line of defense in our bodies. It consists of defense mechanisms that are in place even before infection and are ready to response rapidly to infections. These mechanisms reach only the microbes and the injured cells and respond the same way during each exposure. These include physical and chemical barriers such as the lining in your intestines.
ADAPTIVE immunity is specific or acquired immunity. These immune responses are stimulated by exposure to infectious agents and increase the magnitude and defense capabilities with each successive exposure. This type of immunity develops as a result of infections and adapts to infection. The unique part of the adaptive immunity are cells called lymphocytes and their secreting proteins are called antibodies. Foreign substances that induce these specific immune responses are called antigens.
TYPES OF ADAPTIVE IMMUNE RESPONSE LEADING TO AUTOIMMUNE DISEASE
HUMORAL immunity is made by the molecules from the blood and the mucosal secretions called antibodies. These are produced by the B lymphocytes. Antibodies recognized microbial antigens and neutralize the infectivity.
CELL MEDIATED immunity also called cell immunity is mediated by T lymphocytes. Intracellular microbes such as viruses and some bacteria survive and proliferate inside the cells and under host cells, where they are inaccessible to circulating antibodies. Defense against such infection is the function of the cell mediated immunity which destroys the microbe inside the phagocyte and kills or eliminates the reservoirs of infections.
MECHANISM OF AUTOIMMUNE DISEASE
YOU NEED TO BE TESTED EARLY WITH NEW CUTTING EDGE AUTOANTIBODY TESTING
Your antibodies are large Y-shaped proteins produced in a portion of your immune system known as the B cell and secreted by the white blood cell. Another type of cell known as the T helper cell is needed to active the B cell. The different antibodies of the body work differently. The main one is called IgA and it is the most common and the largest part of the immune system. It is found in the vast majority of your intestinal gut lining and also in your respiratory tract. These antibodies protect you from virus and bacteria and are found in your saliva and breast milk and measuring them is very important.
IgE can measure allergies and these antibodies play a role in allergies not autoimmune disease. In a peanut allergy the IgE goes up. In the IGG type of antibody there is an inflammatory response that is slow and less intense than IgE and response is known as sensitivity rather than allergy. This is called an IgG reaction can be more subtle up to one or two days and lasting even a week. IgG and IGA over-responsiveness leads to autoimmune disease.
When chronic inflammation lasts too long we get AUTOIMMUNE DISEASE.
I MEASURE IGG AND IGA AUTOANTIBODIES TO MANY DIFFERENT FOODS AND CHEMICALS. I ALWAYS MEASURE AUTOANTIBODIES TO YOUR DIFFERENT ORGANS. LEARN WANT TO DO BEFORE YOUR ORGANS ARE AFFECTED.
So now, let’s look at different factors that can turn on the immune response.
CAUSES OF AUTOIMMUNITY
As you recall, autoimmune disease is now the third most prevalent disease after cancer and heart disease and is increasing rapidly around the world. Genetic susceptibility, environmental triggers such dietary components such as wheat and wheat associated foods that have gluten, toxic chemicals such as heavy metal, mercury, formaldehyde, bisphenol A, and other toxins.
The problem for current testing for gluten reactivity and Celiac disease is the testing itself. Tests include serum IgG and IgA against collagen in tissue transglutaminase (tTG2). These antibodies are measured against minor components of the wheat protein called alfa gliadin. They are not adequate.
However, wheat consists of multiple proteins and peptides including alfa gliadin, omega gliadin, glutenin, gluteomorphin, agglutinins and others Please note, that any of these antigens have the ability to challenge the immune system and many are implicated in the development of non gluten celiac sensitivity, as well as celiac sensitivity. I use a specialized autoimmune testing laboratory. These cause autoimmune disease. THESE CAN ALL BE MEASURED.
NON CELIAC GLUTEN SENSITIVITY: AUTOIMMUNE REACTION
This is a gluten reactively that is a systemic autoimmune disease with diverse magnification.
It is unfortunate that celiac disease receives most of the press in this country, although non celiac gluten sensitivity is much more common and goes undiscovered.
Autoimmune disease is ten times more common in a gluten sensitive enteropathy than in the general population. Thus, the burden cannot be over estimated. Early evaluation and early treatment results in better quality of life. The non gluten celiac sensitivity is seen in the skin, psoriatic arthritis, alopecia, dermatomyositis, cutaneous vasculitis, and inflammatory myopathies, to the brain with gluten ataxia and neurotransmitter production, schizophrenia, peripheral neuralgias, as well as idiopathic neuropathies.
GLUTEN PEPTIDES CAUSE AUTOIMMUNITY
During digestion gluten proteins are enzymatically broken down in the GI tract. However, because of the high proline content of gluten the degradation is not sufficient and only large gluten peptides can persist. There are thousands of such peptides produced during digestion and multiple peptides can stimulate immune responses in individuals.
OPIOID PEPTIDES CAUSE AUTOIMMUNITY
These peptides have similar symptoms of that of morphine and opioids and five to six have been identified in the pepsin trypsin digestion of gluten. This morphine like psychoactive nature of the peptide results in incomplete digestion of the dietary protein binding to the opioid receptor of the brain and offers a possible explanation for some of the reported brain problems, panic attacks, and other neurological complaints.
LECTINS CAUSE AUTOIMMUNITY
The wheat germ of glutens are lectins or carbohydrate binding proteins with a capacity to bind to many cells and cell tissues. Lectin binds the cells involving the immune system and induces toxic damage, inflammation, and autoimmunity. For example, a lectin can bind to an autoantibody and cause and autoimmune disease or diabetes. In humans the evidence of incriminating wheat lectin as the cause of IgA neuropathies is now impressive.
ENZYMES CAUSES AUTOIMMUNITY
Transglutaminase are a family of enzymes that form protein like scaffolding which are vital to the barrier and stability. Humans have transglutaminase in many tissues.
Antibodies produced against epithelial cell can cross react with other ones such as bone, brain and skin. In some cases this leads to an autoimmune response in other tissues and they develop osteoporosis, neuro-autoimmunity and skin disorders.
Transglutaminase 3 is expressed mainly in the skin and lesser in the placenta and brain. It is found in gluten sensitive enteropathy with skin disorders called dermatitis herpetiformis which are papules with granular IgA deposits over the extensor surfaces of the major joints. They are also found in Huntington’s disease and others.
Transglutaminase 6 is found in neural tissue that can cause early brain damage and associated inflammation. When high levels are found they are suspected to cause autoimmune against neural tissue manifesting in cerebral palsy, cerebral ataxia, and peripheral neuropathy.
OTHER INFLUENCING FACTORS IN AUTOIMMUNE DISEASE
GENETIC FACTORS CAUSING AUTOIMMUNE DISEASE
Of the general population 40-50% are carriers of the DQ2-DQR gene, however close to 90% of celiac disease patients carry the gene DQ2 and a minority less than 10% of celiac patients carry DQR.
ENVIRONMENTAL FACTORS CAUSES AUTOIMMUNE DISEASE
Environmental factors have played a role in development of autoimmune disease. These include bacteria, virus, cross reactive food, chemicals, heavy metals, and EMF.
GLUTEN ASSOCIATED CROSS REACTIVE FOODS AND SENSITIVITY CAUSE AUTOIMMUNITY
In many cases we tell our patients to restrict gluten but they still have symptoms and they are even eating gluten-free which is even worse.
It has now been found that there is this antigen similarity cross reaction among many different foods.
Gluten free cookies, crackers and breads often contain copious amounts of rice, sorghum, soy, and other substitutes. Patients try quinoa, buckwheat, amaranth or polish wheat, spelt, barley, or rye not knowing that these contain gluten. As they try to avoid gluten they start over consumption of another starch to make up for the loss of wheat. They turn to potato, rice, or corn as a substitute; this again can lead to a sensitivity. Remember you have to read the labels. The World Health Organization allows the inclusion of up to .3 protein from gluten containing foods in foods labeled gluten-free. Beer also has gluten.
Wheat/ gliadin is commonly added to food as a hidden ingredient such as natural flavors or spices and the problem with digesting dairy in particular is that Casein sensitivity to cows, sheep, and goats milk.
So even though a person may be on a gluten-free diet, they are still having symptoms.
Casein has been implicated in Behcet’s disease, type I diabetes and lupus. Other cross reaction foods milk, Casein, yeast, as mentioned polish wheat, spelt, millet, corn, yeast, rice, oats, and coffee. A person may also have a gluten reaction may be reactive to eggs or soybean.
In this case, I test for rye, barley, polish wheat, spelt, cow’s milk, casein, casomorphin, milk, whey protein, buckwheat, sesame, corn, yeast, oats, chocolate milk, sorghum, millet, hemp, amaranth, quinoa, tapioca, potato, rice, corn, eggs, soy and others.
In addition to the other foods there is now a NEW food AUTOANTIBODY TESTING screen testing for over 180 foods to evaluate the immune reaction to foods, raw and modified foods, food enzymes, lectins, and artificial food additives including meat glue and colorings in gum.
That is, they are testing real food, cooked and lean and food combinations, I think it is extremely important. Another test is to do predictive autoimmunity testing that evaluates the antibodies long before there is a symptomatic systemic disease. I am talking ten or twenty years prior in the organs involved.
So, as you can see, the testing for these foods, as well as testing for heavy metal autoantibodies and toxic antibodies, I think is very, very important. As far as the role of genes we know that the risk is about one-third for genes and the remainder is due to non-hereditary risks.
So after looking at diet and environmental factors we need to look at INFECTIOUS agents.
These include viruses such as HHV6, Epstein-Barr, herpes, H. pylori, yersinia, chlamydia pneumonia, candida, mycoplasma and many more. Lyme can also be added to this list.
THE MICRO BIOME IMBALANCE CAUSES AUTOIMMUNITY
When there is abnormal colonic microbiome there is a release of lipopolysaccharide endotoxins from gram negative rods with subsequent loss of immune tolerance, gut inflammation, and subsequent intestinal permeability becomes dysfunctional and the endotoxin lipopolysaccharide enters the circulation and with that comes loss of the blood brain barrier and associated abnormalities of the humoral and cell mediated immune responses all causing autoimmune disease.
These react with various tissues such as the liver, brain, muscle, joint, kidney, pancreas, diabetes and others to form a multisystemic autoimmune disease.
Remember the microbiome is associated with brain function and the introduction of a new tolerance. It relates to the mucosal immune function, as well as systemic immune function and intestinal barrier integrity, nutrition and metabolism, body weight and autoimmune disease.
The point is here, the microbiome needs to be kept healthy.
If the microbiome is exposed to good things like lactobacillus acidophilus and good bacteria there is an increase in the ratio of Treg to Th1 and Th17 cells. Remember Treg cells are regulatory and suppress the immune system to keep it balanced. That is a good scenario. If there is increase in bad bacteria and abnormalities in the mucosal immune system, there is then a decrease in the ratio of Treg to Th1 and Th17 cells, and with this decrease Th17 overwhelms the system to cause massive destruction.
So both the intestinal permeability needs to be measured.
The TESTING involves mucosal immune screening, intestinal antigenic permeability screening, dietary components with gluten and non-gluten foods, lectins, gum, cooked and raw, etc, and predictable autoantibody screening to find out what organs are involved and then to look at the chemical, as well as infectious immune screening.
When these are completed, I preform an evaluation of mitochondrial function to evaluate amino acids, fatty acids, free radicals, oxidative stress, amount of mutation, antioxidant levels to maintain optimal status, and to repair the mitochondria.
In addition to this, I do a stimulated cytokine panel and see where exactly Th1, Th2, Treg cells, Th17 cells are at the time of the patient’s disease. Of course, CD4, CD8 and natural killer cells are measured along with heavy metals and viral titers, as well as looking for Lyme disease if I suspect it.
My treatments include removing the triggers, detoxifying the body, treat.
I repair the barriers by increasing Treg cells and decreasing pathogenic Th17 cells. To this effect, I use artemisinin, glutamine, vitamin A, vitamin D, probiotics, FOS , EPA, DHA, green tea extracts, resveratrol, curcumin, Boswellia, cruciferous vegetables,, and good flora for healthy microbes.
I also remove heavy metals through chelation and lower viral counts and kill infections like Lyme with ozone and ultraviolet blood irradiation. Detoxification is also carried out with multiple
IV THERAPIES WHICH ARE ALL PERSONALIZED.
I feel that vaccines can cause and aggravate an underlying autoimmune situation and are extremely.
THE GUT AUTOIMMUNE CONNECTION
When there is evidence of maldigestion, leaky gut, and GI infection, a new complex is formed. For example, the mucous membrane of healthy people is colonized by Bifidobacteria, Lactobacillus, Bacteroides, and Enterococci.
The mucous membrane in rheumatoid arthritis subjects is mainly colonized by aerobic opportunistic conventional pathogenic enterobacteria such as Escherichia coli, Citrobacter, Enterobacter, Klebsiella, etc., Staphylococci, Enterococci and anaerobic bacteria such as Peptococci. Taking into account significant changes of colonization resistance in the colon mucosa membranes in the remission period of RA, it may be necessary to apply bacterial therapy using bacterial drugs containing Bifidobacteria and Lactobacteria.
There has also been found to be a link between intestinal permeability and inflammatory joint disease. That is, joint disease may be triggered through the gut.
Sophisticated stool studies may also check for evidence of inflammation and mucosal health. I routinely obtain these in my patients.
There are of course gene factors associated in autoimmune disorders.
There has been an increased incidence of autoimmune diseases in families and increased incidence of autoantibody in the relatives of these patients as well as an increase incidence of diseases in monozygotic twins. Gene factors in autoimmune disease have been located in chromosome 6 in the HLA regions.
Of note is that these autoantibodies occur before clinical onset of disease and are predictive of autoimmunity. Several nonrandomized small scale studies have suggested that autoimmune disease could be prevented if treated aggressively prior to the manifestations of symptoms. Individuals who are at high risk of developing autoimmune disease should be advised to refrain from activities and lifestyles which endanger their health and quality of life.
HORMONAL FACTORS OF AUTOIMMUNE DISORDER
Hormones, especially the female hormones of estrogen, have been implicated in autoimmune disorders. There have also been associated medications causing autoimmune disease.
DIET AND AUTOIMMUNE DISEASE
There is increasing evidence that the loss of intestinal barrier function typical of celiac disease and gluten sensitivity could be responsible for the onset of other autoimmune diseases. The autoimmune response can be theoretically stopped and perhaps reversed if the interplay between autoimmune predisposing genes and triggers is prevented or eliminated by a prompt diagnosis and the treatment with a gluten-free diet. This has been published in the Current Opinion Gastroenterology 2006 in November. Other studies have shown that low concentration of arachidonic acid and high concentrations of the long chain N-3 fatty acids improve autoimmunity.
Vitamin D levels show an inverse relationship between multiple sclerosis, type 1 diabetes, rheumatoid arthritis, and inflammatory bowel disorder.
Of interest to note, patients with autoimmune disease express genetic polymorphism of Vitamin D regulatory genes. This would prompt all patients to check their vitamin D levels and vitamin D genes. Physical and psychological stressors are also implicated in the development of autoimmune disorder. Approximately 86% of patients reported uncommon emotional stress before disease onset.
WHAT DO ALL THESE FACTORS HAVE IN COMMON?
They all contribute to “information” to modulate genetic expression of the immune system that can create cross-talk between self and nonself. The production of molecules through the exposure to chemicals, endogenous metabolites such as mercury, estrogens, etc., modify cellular composition and alteration of proteins, all contributing to the immune system to recognize the body as being foreign.
IMMUNE FACTORS IN AUTOIMMUNE DISORDERS
In autoimmune disease, there is modification of proteins with chemically altered DNA involving cross-linking, methylation, and oxidation. These epigenetic modifications can be controlled by diet nutrients and intestinal flora, and they have been found to influence methylation acetylation related to the epigenetic process. These modifications of DNA have been demonstrated to have the potential to be passed on to the next generation, so we need to silence the abnormal immune system.
SUMMARY ON TESTING AND TREATMENT FOR AUTOIMMUNE DISEASE
Autoimmune disease is on the rise. These include organ specific and organ nonspecific but its just an arbitrary definition. I believe that all brain diseases including Alzheimer’s, traumatic brain injury, Parkinson’s, multiple sclerosis, and amyotrophic lateral sclerosis are all autoimmune in nature. We know may others such as type I diabetes, Hashimoto’s thyroiditis, joint disease and even heart disease can be from autoantibodies. The list goes on and on.
You need to repair your intestinal tract, intestinal permeability and repair your tight junctions. The microbiome needs to be balanced.
Your viral load has to be lower. Your metals have to be lower.
Your blood brain barrier autoantibodies have to decrease and your humoral and T cell abnormalities causing the destruction must be down regulated by Treg cells and others.
You need to know exactly what foods to avoid for the rest of your life.
In addition to this, the mitochondrial dysfunction that is involved must be improved, cytokines balanced and the elevated blood sugars must come down, as well as losing weight, sleeping 7 to 8 hours a night, and maintain a low saturated fat organic mostly plant based, nuts and seeds, non GMO diet, and no trans fats. I have reversed many cases of Crohn’s disease, as well as multiple sclerosis and other autoimmune diseases. It all starts with being informed of the reasons and triggers and how to reverse them.